Some highlights of the Melissa Neels band include opening for Chuck Berry at Blueberry Hill, performing at the St. Louis Big Muddy blues festival - their fifth appearance, playing the Sparta blues festival in Sparta IL, featuring Little Milton, performing on Channel 2 Fox morning show twice, playing in the second annual Baby Blues Showcase at BB's Jazz, Blues and Soups, playing the STLBlues.net benefits, and performing on the Becky Thatcher featuring the Blues Cruise. We've also performed at the St. Louis Art fair, and the Whittaker Music Festival at the Missouri Botanical Gardens.

The band members of the Melissa Neels band consists of Melissa Neels on vocals, lead guitar and rhythm guitar, Matt McCauley on keyboards, Bobby K. on bass, and Tom May on drums.